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DIFFERENCES IN PRIMARY STRUCTURE BETWEEN ISOENZYMES OF HORSE LIVER ALCOHOL DEHYDROGENASE

被引：12
作者：
JORNVALL, H
机构：
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 35卷 / 04期
关键词：
D O I：
10.1016/0006-291X(69)90381-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The main form of each of the three isoenzyme groups of horse liver alcohol dehydrogenase has been investigated by fingerprinting techniques. Three amino acid substitutions causing differences in the primary structure between the two protein chains forming the isoenzymes were detected. These replacements make one chain more hydrophobic than the other but give no explanation for the apparent differences in charge between the isoenzymes. All three substitutions are compatible with single base mutations and a common genetic origin is suggested. © 1969.
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页码：542 / &
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