NITRITE PROMOTES LYMPHOMA INCIDENCE IN RATS

被引：75

作者：

NEWBERNE, PM

机构：

[1] Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge

来源：

SCIENCE | 1979年 / 204卷 / 4397期

关键词：

D O I：

10.1126/science.451551

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rats were exposed to sodium nitrite in food or water at concentrations of 0, 250, 500, 1000, and 2000 parts per million. Lymphoma was increased in all groups fed nitrite; the overall combined incidence was 5.4 percent in 573 control rats and 10.2 percent in 1383 treated rats. The mechanism of cancer induction did not appear to be through the formation of nitrosamines but through a more direct effect of nitrite on the lymphocyte. Copyright © 1979 AAAS.

引用

页码：1079 / 1081

页数：3

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