EVIDENCE FOR THE HISTAMINE-MEDIATED MYOTROPIC EFFECT OF ANGIOTENSIN-II IN THE RABBIT AORTA

被引：7

作者：

ERCAN, ZS

ERSOY, FF

BOKESOY, TA

TURKER, RK

机构：

[1] HACETTEPE UNIV, FAC MED, DEPT MED & SURG RES, ANKARA, TURKEY

[2] UNIV ANKARA, FAC MED, DEPT PHARMACOL, ANKARA, TURKEY

来源：

PHARMACOLOGY | 1979年 / 18卷 / 05期

关键词：

Angiotensin II; Induced histamine; Rabbit aorta;

D O I：

10.1159/000137264

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Histamine H1-receptor antagonist mepyramine and H2-receptor antagonist metiamide, respectively, diminished and potentiated angiotensin II (A II)-induced myotropic responses in the rabbit aortic strips. The responses of the octapeptide were inhibited in the presence of histidine decarboxylase inhibitor 2-hydroxy-5-carbomethoxybenzoxyamine and restored when subcontractile quantities of histamine were added to the inhibitor-containing medium. Inhibition of histamine degradation by aminoguanidine potentiated A II''s responses. Apparently A II-induced histamine synthesis in the test preparation.

引用

页码：276 / 279

页数：4

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