PLACENTA-BOUND IMMUNOGLOBULINS

被引：6

作者：

JURJUS, A ^{[1
]}

WHEELER, DA ^{[1
]}

GALLO, RC ^{[1
]}

WITZ, IP ^{[1
]}

机构：

[1] NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20205

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 11期

关键词：

D O I：

10.1002/art.1780221120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low pH eluates were prepared from trophoblasts derived from 8 term human placentas. A qualitative analysis for immunoglobulins revealed the presence of IgG, IgA, and IgM in these eluates. IgG‐rich fractions were obtained by DEAE‐cellulose chromatography of ammonium sulfate‐concentrated eluates. These fractions were able to neutralize, in vitro, the catalytic activity of reverse transcriptases (RT) from several retroviruses. RT from baboon endogenous virus (BEV) seemed to be more susceptible to the neutralizing activity of some eluates. This was in contrast to RT from feline leukemia virus (FeLV) which were neutralized by eluates of leukocytes from chronic myelogenous leukemia. In contrast to previous and present results with purified IgG from leukemic leukocytes, the purified IgG from placenta eluates was incapable of RT neutralization. However, such purified IgG fractions inhibited mixed lymphocyte reactions. Copyright © 1979 American College of Rheumatology

引用

页码：1308 / 1313

页数：6

共 20 条

[1]

BEER AE, 1975, MODERN PERINATAL MED, P83

[2]

BONNEAU M, 1973, TRANSPL P, V5, P589

[3] ULTRASTRUCTURAL COMPARISON OF PLACENTAL VIRUS WITH SEVERAL TYPE-C ONCOGENIC VIRUSES [J].