A POPULATION CYTOGENETIC STUDY OF A COMMON FRAGILE SITE, FRA(3)(P14), IN A HEALTHY POPULATION

被引：3

作者：

MURATA, M ^{[1
]}

OTSUKA, M ^{[1
]}

HAYAKAWA, Y ^{[1
]}

TAKAHASHI, E ^{[1
]}

TSUJI, H ^{[1
]}

HORI, TA ^{[1
]}

机构：

[1] NATL INST RADIOL SCI,DIV GENET,CHIBA 260,JAPAN

来源：

JAPANESE JOURNAL OF HUMAN GENETICS | 1990年 / 35卷 / 04期

关键词：

FRA(3)(P14); FOLATE DEFICIENCY; APHIDICOLIN; CELL CYCLE; AGE;

D O I：

10.1007/BF01883751

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A population survey of a common folate-sensitive fragile site, fra(3)(p14), was carried out on PHA-stimulated peripheral lymphocytes of 1,078 healthy subjects. Fra(3)(p14) was expressed more frequently in the younger than in the older, and in males than in females. It also showed some seasonal variation. The age difference of the expression frequency was also observed by aphidicolin treatment. A positive correlation of the expression frequency was found, though not so strongly, between both culture conditions of folate deprivation and aphidicolin treatment, These findings suggest that the inter-individual variation in the expressivity of common fragile sites is not only ascribable to chance, but to some physiological conditions of blood donors such as response rate of lymphocyte to PHA stimulation and blood concentration of folic acid.

引用

页码：291 / 302

页数：12

共 16 条

[1] VARIATION IN THE EXPRESSION OF APHIDICOLIN-INDUCED FRAGILE SITES IN HUMAN-LYMPHOCYTE CULTURES [J].