EFFECTS OF ATROPINE ON HIPPOCAMPAL THETA-CELLS AND COMPLEX-SPIKE CELLS

被引:30
作者
STEWART, M [1 ]
LUO, YQ [1 ]
FOX, SE [1 ]
机构
[1] SUNY HLTH SCI CTR,DEPT PHYSIOL,BROOKLYN,NY 11203
关键词
INTERNEURON; PYRAMIDAL CELL; THETA RHYTHM; RHYTHMICAL SLOW ACTIVITY;
D O I
10.1016/0006-8993(92)90986-J
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The medial septal nuclei are essential for the naturally occurring hippocampal theta rhythm. Evidence that the rhythmic activity of the septum is carried via cholinergic afferents to the hippocampus has been: (a) the existence of a cholinergic septo-hippocampal projection, and (b) the sensitivity of one type of theta rhythm to antimuscarinic agents or cholinergic depletion. The muscarinic action of acetylcholine on pyramidal cells, however, is too slow to carry even a 4 Hz signal. Recent in vitro studies have confirmed a fast excitatory response by some hippocampal interneurons to muscarinic agonists. In urethane anesthetized rats, iontophoretic application of atropine to 17 hippocampal theta cells (presumed interneurons) during the theta rhythm, reduced their firing rates to an average of 24% of control rates. The effect of iontophoretic atropine application to 4 CA1 complex-spike cells (presumed pyramidal cells) was a selective elimination of their bursting activity with no significant effect on overall firing rate. The data suggest that: (1) interneuronal firing, during the hippocampal theta rhythm, is dominated by an excitatory cholinergic input and not by excitatory collaterals of pyramidal cells; and (2) somatic burst firing by CA1 pyramidal cells requires the presence of acetylcholine.
引用
收藏
页码:122 / 128
页数:7
相关论文
共 37 条
[1]   AN ANALYSIS OF THE ORIGINS OF THE CHOLINERGIC AND NONCHOLINERGIC SEPTAL PROJECTIONS TO THE HIPPOCAMPAL-FORMATION OF THE RAT [J].
AMARAL, DG ;
KURZ, J .
JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 240 (01) :37-59
[2]   SEPTO-HIPPOCAMPAL PATHWAY NECESSARY FOR DENTATE THETA PRODUCTION [J].
ANDERSEN, P ;
BLAND, HB ;
MYHRER, T ;
SCHWARTZKROIN, PA .
BRAIN RESEARCH, 1979, 165 (01) :13-22
[3]   CHOLINERGIC AND NON-CHOLINERGIC SEPTO-HIPPOCAMPAL PROJECTIONS - A DOUBLE-LABEL HORSERADISH PEROXIDASE-ACETYLCHOLINESTERASE STUDY IN THE RABBIT [J].
BAISDEN, RH ;
WOODRUFF, ML ;
HOOVER, DB .
BRAIN RESEARCH, 1984, 290 (01) :146-151
[4]   CHOLINERGIC PHARMACOLOGY OF MAMMALIAN HIPPOCAMPAL PYRAMIDAL CELLS [J].
BENARDO, LS ;
PRINCE, DA .
NEUROSCIENCE, 1982, 7 (07) :1703-1712
[5]   CHOLINERGIC EXCITATION OF MAMMALIAN HIPPOCAMPAL PYRAMIDAL CELLS [J].
BENARDO, LS ;
PRINCE, DA .
BRAIN RESEARCH, 1982, 249 (02) :315-331
[6]   IONIC MECHANISMS OF CHOLINERGIC EXCITATION IN MAMMALIAN HIPPOCAMPAL PYRAMIDAL CELLS [J].
BENARDO, LS ;
PRINCE, DA .
BRAIN RESEARCH, 1982, 249 (02) :333-344
[7]  
BRUCKE F, 1959, N-S ARCH EX PATH PH, V237, P276
[8]   DIRECT AFFERENT EXCITATION AND LONG-TERM POTENTIATION OF HIPPOCAMPAL INTERNEURONS [J].
BUZSAKI, G ;
EIDELBERG, E .
JOURNAL OF NEUROPHYSIOLOGY, 1982, 48 (03) :597-607
[9]   THE PHARMACOLOGY OF CHOLINERGIC EXCITATORY RESPONSES IN HIPPOCAMPAL PYRAMIDAL CELLS [J].
COLE, AE ;
NICOLL, RA .
BRAIN RESEARCH, 1984, 305 (02) :283-290
[10]   THE ACTION OF PROCAINE AND ATROPINE ON SPINAL NEURONES [J].
CURTIS, DR ;
PHILLIS, JW .
JOURNAL OF PHYSIOLOGY-LONDON, 1960, 153 (01) :17-34