CIGARETTE-SMOKING - A REVIEW OF POSSIBLE ASSOCIATIONS WITH BENIGN PROSTATIC HYPERPLASIA AND PROSTATE-CANCER

被引:36
作者
MATZKIN, H [1 ]
SOLOWAY, MS [1 ]
机构
[1] UNIV MIAMI, SCH MED, DEPT UROL, POB 016960, M814, MIAMI, FL 33101 USA
关键词
BPH; ANDROGENS; ESTROGENS;
D O I
10.1002/pros.2990220402
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There are conflicting data on the effect of cigarette smoking on serum levels of the various sex hormones. Some studies suggest that cigarette smoke produces an antiestrogenic effect. Smoking may also affect the metabolism of other sex steroids such as testosterone and adrenal hormones, and thereby influence the incidence of benign and malignant growth of the prostate. Epidemiologic studies analyzing a possible association between cigarette smoking and prostate cancer are not conclusive, although some show a positive relationship. The etiology of BPH is undoubtedly multifactorial. Estrogens as well as androgens may be involved in the pathogenesis of BPH. There are several studies that indicate that cigarette smokers have a lower likelihood of requiring surgery for BPH. Growth of the prostate may not correlate with serum levels of androgens and estrogens. The local hormonal milieu of the target cells in the prostate are probably more critical than the more easily measured serum levels. This review examines the literature dealing with cigarette smoking and both BPH and prostate cancer. If there is an effect, then elucidation of the mechanism by which smoking affects the growth of the prostate may improve our understanding of BPH and prostate cancer, and may suggest preventive strategies for high risk groups. (C) 1993 Wiley-Liss, Inc.
引用
收藏
页码:277 / 290
页数:14
相关论文
共 74 条
[1]   HIGH-RISK GROUP FOR BENIGN PROSTATIC HYPERTROPHY [J].
ARAKI, H ;
WATANABE, H ;
MISHINA, T ;
NAKAO, M .
PROSTATE, 1983, 4 (03) :253-264
[2]  
ARMENIAN HK, 1974, LANCET, V2, P115
[3]   EPIDEMIOLOGIC CHARACTERISTICS OF PATIENTS WITH PROSTATIC NEOPLASMS [J].
ARMENIAN, HK ;
LILIENFELD, AM ;
DIAMOND, EL ;
BROSS, IDJ .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1975, 102 (01) :47-54
[4]  
BARBIERI RL, 1986, FERTIL STERIL, V46, P232
[5]   NICOTINE, COTININE, AND ANABASINE INHIBIT AROMATASE IN HUMAN TROPHOBLAST INVITRO [J].
BARBIERI, RL ;
GOCHBERG, J ;
RYAN, KJ .
JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (06) :1727-1733
[6]   SMOKING AND ESTROGEN-RELATED DISEASE [J].
BARON, JA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1984, 119 (01) :9-22
[7]   CIGARETTE-SMOKING AND PROLACTIN IN WOMEN [J].
BARON, JA ;
BULBROOK, RD ;
WANG, DY ;
KWA, HG .
BRITISH MEDICAL JOURNAL, 1986, 293 (6545) :482-483
[8]   DNA-SYNTHESIS IN THE CANINE PROSTATE - EFFECTS OF ANDROGEN AND ESTROGEN-TREATMENT [J].
BARRACK, ER ;
BERRY, SJ .
PROSTATE, 1987, 10 (01) :45-56
[9]   CIGARETTE-SMOKING AND INCREASED ENDOGENOUS ESTROGEN-LEVELS IN MEN [J].
BARRETTCONNOR, E ;
KHAW, KT .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1987, 126 (02) :187-192
[10]   A PROSPECTIVE-STUDY OF DEHYDROEPIANDROSTERONE SULFATE, MORTALITY, AND CARDIOVASCULAR-DISEASE [J].
BARRETTCONNOR, E ;
KHAW, KT ;
YEN, SSC .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (24) :1519-1524