AQUATIC PHOTODEGRADATION OF ALBENDAZOLE AND ITS MAJOR METABOLITES .1. PHOTOLYSIS RATE AND HALF-LIFE FOR REACTIONS IN A TUBE

被引：15

作者：

WEERASINGHE, CA ^{[1
]}

LEWIS, DO ^{[1
]}

MATHEWS, JM ^{[1
]}

JEFFCOAT, AR ^{[1
]}

TROXLER, PM ^{[1
]}

WANG, RY ^{[1
]}

机构：

[1] RES TRIANGLE INST,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1992年 / 40卷 / 08期

关键词：

D O I：

10.1021/jf00020a025

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Aquatic photodegradation of albendazole (ABZ) and its three major metabolites, albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO2), and 2-aminoalbendazole sulfone (ABZ2NH2), was studied under natural sunlight. The sun light exposures were conducted in solution at pH 5, 7, and 9 to encompass conditions of reversible ionization or protonation of the test substances. The photodegradation rate constants and half-lives were determined for the test substances. An HPLC method was used to measure the disappearance of chemical in solution with time. The substances degraded rapidly with photolytic half-lives (t1/2) for ABZ, ABZSO, ABZSO2, and ABZ2NH2 Of 0.012-0.031, 0.096-0.33, 0.041-0.91, and 0.35-0.81 days, respectively. The reaction quantum yield (PHI) was measured at each pH and will be presented in part 2 of this presentation.

引用

页码：1413 / 1418

页数：6

共 8 条

[1] DEVELOPMENT AND EVALUATION OF SUNLIGHT ACTINOMETERS [J].