TOTAL SYNTHESIS OF THE TREHALASE INHIBITORS TREHALOSTATIN AND TREHAZOLIN, AND OF THEIR DIASTEREOISOMERS - FINAL STRUCTURAL CONFIRMATION OF THE INHIBITOR

被引：45

作者：

UCHIDA, C ^{[1
]}

YAMAGISHI, T ^{[1
]}

OGAWA, S ^{[1
]}

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT APPL CHEM,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 05期

关键词：

D O I：

10.1039/p19940000589

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Potent trehalase inhibitors 1-4 have been synthesized, thereby establishing both the structure and the absolute configuration of the known inhibitor trehazolin 2. Compound 1, previously proposed as the structure of trehalostatin, and its diastereoisomer 3, have been shown not to possess any observable inhibitor activity against trehalase. These results indicate that the initial structure assigned for trehalostatin is incorrect, and that its structure is identical with that of trehazolin 2.

引用

页码：589 / 602

页数：14

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