U-500 INSULIN IN THE TREATMENT OF ANTIBODY-MEDIATED INSULIN RESISTANCE

被引：22

作者：

NATHAN, DM

AXELROD, L

FLIER, JS

CARR, DB

机构：

[1] MASSACHUSETTS GEN HOSP, MED SERV, BOSTON, MA 02114 USA

[2] BETH ISRAEL HOSP, MED SERV, BOSTON, MA 02215 USA

[3] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA

来源：

ANNALS OF INTERNAL MEDICINE | 1981年 / 94卷 / 05期

关键词：

D O I：

10.7326/0003-4819-94-5-653

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three patients with antibody-mediated insulin resistance were treated with U-500 regular insulin s.c. Insulin requirements decreased dramatically (55-75%) when therapy was changed from U-100 NPH pork to equivalent doses of U-500 regular pork insulin. There was no difference in antibody affinity for the insulin in these 2 preparations as shown by competition experiments. U-500 insulin is a useful alternative in the treatment of antibody-mediated insulin resistance. The mechanism for this effect is yet to be determined.

引用

页码：653 / 656

页数：4

共 9 条

[1]

BINDER C, 1969, ACTA PHARMACOL TOX, VS 27, P1

[2] IMMUNOLOGICAL INSULIN RESISTANCE [J].