INVIVO EFFECTS OF DIFLUOROMETHYLORNITHINE ON TRYPANOTHIONE AND POLYAMINE LEVELS IN BLOOD-STREAM FORMS OF TRYPANOSOMA-BRUCEI

被引:153
作者
FAIRLAMB, AH [1 ]
HENDERSON, GB [1 ]
BACCHI, CJ [1 ]
CERAMI, A [1 ]
机构
[1] PACE UNIV,HASKINS LABS,NEW YORK,NY 10038
关键词
D O I
10.1016/0166-6851(87)90105-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:185 / 191
页数:7
相关论文
共 32 条
[1]   CONTENT, SYNTHESIS, AND FUNCTION OF POLYAMINES IN TRYPANOSOMATIDS - RELATIONSHIP TO CHEMOTHERAPY [J].
BACCHI, CJ .
JOURNAL OF PROTOZOOLOGY, 1981, 28 (01) :20-27
[2]   POLYAMINE METABOLISM - A POTENTIAL THERAPEUTIC TARGET IN TRYPANOSOMES [J].
BACCHI, CJ ;
NATHAN, HC ;
HUTNER, SH .
SCIENCE, 1980, 210 (4467) :332-334
[3]   INVIVO EFFECTS OF ALPHA-DL-DIFLUOROMETHYLORNITHINE ON THE METABOLISM AND MORPHOLOGY OF TRYPANOSOMA-BRUCEI-BRUCEI [J].
BACCHI, CJ ;
GAROFALO, J ;
MOCKENHAUPT, D ;
MCCANN, PP ;
DIEKEMA, KA ;
PEGG, AE ;
NATHAN, HC ;
MULLANEY, EA ;
CHUNOSOFF, L ;
SJOERDSMA, A ;
HUTNER, SH .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1983, 7 (03) :209-225
[4]   UPTAKE OF ALPHA-DIFLUOROMETHYLORNITHINE BY TRYPANOSOMA-BRUCEI-BRUCEI [J].
BITONTI, AJ ;
BACCHI, CJ ;
MCCANN, PP ;
SJOERDSMA, A .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) :351-354
[5]   NECESSITY OF ANTIBODY-RESPONSE IN THE TREATMENT OF AFRICAN TRYPANOSOMIASIS WITH ALPHA-DIFLUOROMETHYLORNITHINE [J].
BITONTI, AJ ;
MCCANN, PP ;
SJOERDSMA, A .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) :331-334
[6]   CATALYTIC IRREVERSIBLE INHIBITION OF TRYPANOSOMA-BRUCEI-BRUCEI ORNITHINE DECARBOXYLASE BY SUBSTRATE AND PRODUCT ANALOGS AND THEIR EFFECTS ON MURINE TRYPANOSOMIASIS [J].
BITONTI, AJ ;
BACCHI, CJ ;
MCCANN, PP ;
SJOERDSMA, A .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (10) :1773-1777
[7]  
DEGEE ALW, 1983, J PARASITOL, V69, P818, DOI 10.2307/3281038
[8]  
Fahey R.C., 1983, P251
[9]   IDENTIFICATION OF A NOVEL, THIOL-CONTAINING COFACTOR ESSENTIAL FOR GLUTATHIONE-REDUCTASE ENZYME-ACTIVITY IN TRYPANOSOMATIDS [J].
FAIRLAMB, AH ;
CERAMI, A .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1985, 14 (02) :187-198
[10]   TRYPANOTHIONE - A NOVEL BIS(GLUTATHIONYL)SPERMIDINE COFACTOR FOR GLUTATHIONE-REDUCTASE IN TRYPANOSOMATIDS [J].
FAIRLAMB, AH ;
BLACKBURN, P ;
ULRICH, P ;
CHAIT, BT ;
CERAMI, A .
SCIENCE, 1985, 227 (4693) :1485-1487