AMINOGLYCOSIDE ANTIBIOTICS .12. EFFECT OF N-ALKYLATION IN KANAMYCIN ANTIBIOTICS

被引：5

作者：

NAKAGAWA, S

TODA, S

ABE, Y

YAMASHITA, H

FUJISAWA, KI

NAITO, T

KAWAGUCHI, H

机构：

[1] Bristol-Banyu Research Institute, Ltd., Meguro, Tokyo

来源：

JOURNAL OF ANTIBIOTICS | 1978年 / 31卷 / 07期

关键词：

D O I：

10.7164/antibiotics.31.675

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four N-ethyl derivatives of kanamycin A and five N-ethyl derivatives of kanamycin B were synthesized. The antimicrobial activity of N-ethyl kanamycin derivatives was determined against aminoglycoside-sensitive and resistant organisms. The structure-activity relationship of these compounds is discussed with reference to the activity of N-acyl kanamycin derivatives. © 1978, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：675 / 680

页数：6

共 9 条

[1] BB-K8, - NEW SEMISYNTHETIC AMINOGLYCOSIDE ANTIBIOTIC [J].