MUTATION-INDUCTION IN V79 CHINESE-HAMSTER CELLS BY VERY HEAVY-IONS

被引：42

作者：

KRANERT, T

SCHNEIDER, E

KIEFER, J

机构：

[1] Strahlenzentrum der Justus-Liebig-Universität, Giessen

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1990年 / 58卷 / 06期

关键词：

D O I：

10.1080/09553009014552291

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutation induction (resistance to 6-thioguanine) in Chinese hamster fibroblasts (V79) by exposure to accelerated heavy ions (O, Ne, Ca, Ti, Ni, Xe, Pb and U with energies between 5 and 14.8 MeV/u) was investigated, covering a range of LET from 300 to about 15 700 KeV/μm. The LET-dependence of the mutation induction cross-section (σm) has, in a similar way to inactivation (σi), to be described by separate curves for each ion. Both σm and mutagenicity (σm/σi) decrease with increasing specific energy for any given ion. Relative biological effectiveness for mutation induction was found to be significantly smaller than unity for the ions and energies investigated. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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页码：975 / 987

页数：13

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