MEMBRANE FLUIDITY AND FATTY-ACID COMPOSITION OF PHOSPHOLIPIDS IN ERYTHROCYTE-MEMBRANES OF PATIENTS WITH HUNTINGTON DISEASE

被引：11

作者：

ABOOD, ME

BUTLER, M

机构：

[1] Center for Brain Research, University of Rochester Medical Center, Rochester, New York

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1979年 / 4卷 / 03期

关键词：

erythrocytes; fatty acids; Huntington disease; membrane fluidity; phospholipids;

D O I：

10.1002/jnr.490040305

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A study was undertaken to determine whether alterations in the configuration of erythrocyte membranes of patients with Huntington disease, reported by other investigators, could be reflected in membrane fluidity‐viscosity. Since membrane fluidity appears to be related to the fatty acid composition of membrane phospholipids, these were also examined. Membrane fluidity, which was determined by measuring the intrinsic fluorescence of membranous tryptophan, was found to be normal. Although the range of fatty acid distribution within the various phospholipids tended to vary somewhat, the pattern was not significantly different from that of the controls. Copyright © 1979 Alan R. Liss, Inc.

引用

页码：183 / 187

页数：5

共 14 条

[1] MUSCARINIC CHOLINERGIC BINDING IN HUMAN ERYTHROCYTE-MEMBRANES
ARONSTAM, RS
ABOOD, LG
MACNEIL, MK
[J]. LIFE SCIENCES, 1977, 20 (07) : 1175 - 1180
[2] Borri P, 1966, Psychiatr Neurol Neurochir, V69, P143
[3] ELECTRON-SPIN RESONANCE STUDY OF MEMBRANE-PROTEIN ALTERATIONS IN ERYTHROCYTES IN HUNTINGTONS-DISEASE
BUTTERFIELD, DA
OESWEIN, JQ
MARKESBERY, WR
[J]. NATURE, 1977, 267 (5610) : 453 - 455
[4] INCREASED SODIUM PLUS POTASSIUM ADENOSINE-TRIPHOSPHATASE ACTIVITY IN ERYTHROCYTE-MEMBRANES IN HUNTINGTONS-DISEASE
BUTTERFIELD, DA
OESWEIN, JQ
PRUNTY, ME
HISLE, KC
MARKESBERY, WR
[J]. ANNALS OF NEUROLOGY, 1978, 4 (01) : 60 - 62
[5] DIFFERENTIAL SCANNING CALORIMETRY AND P-31 NMR-STUDIES ON SONICATED AND UNSONICATED PHOSPHATIDYLCHOLINE LIPOSOMES
DEKRUIJFF, B
CULLIS, PR
RADDA, GK
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 406 (01) : 6 - 20
[6] GOLDSTEIN BD, 1976, BLOOD CELLS, V2, P535
[7] FLUIDITY IN HYDROPHOBIC PROTEIN REGIONS OF SYNAPTIC-MEMBRANES
HOSS, W
ABOOD, LG
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1974, 50 (01): : 177 - 181
[8] SCANNING ELECTRON-MICROSCOPY STUDIES OF ERYTHROCYTES IN HUNTINGTONS-DISEASE
MARKESBERY, WR
BUTTERFIELD, DA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 78 (02) : 560 - 564
[9] MCCONNELL HM, 1970, NEUROSCIENCES 2 STUD, P697
[10] REED CF, 1960, J LAB CLIN MED, V56, P281

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