FUNCTIONAL-ORGANIZATION OF PRIMATE VISUAL-CORTEX REVEALED BY HIGH-RESOLUTION OPTICAL IMAGING

被引:416
作者
TSO, DY
FROSTIG, RD
LIEKE, EE
GRINVALD, A
机构
[1] IBM CORP,DIV RES,YORKTOWN HTS,NY 10598
[2] WEIZMANN INST SCI,IL-76100 REHOVOT,ISRAEL
关键词
D O I
10.1126/science.2165630
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A high spatial resolution optical imaging system was developed to visualize cerebral cortical activity in vivo. This method is based on activity-dependent intrinsic signals and does not use voltage-sensitive dyes. Images of the living monkey striate (V1) and extrastriate (V2) visual cortex, taken during visual stimulation, were analyzed to yield maps of the distribution of cells with various functional properties. The cytochrome oxidase-rich blobs of V1 and the stripes of V2 were imaged in the living brain. In V2, no ocular dominance organization was seen, while regions of poor orientation tuning colocalized to every other cytochrome oxidase stripe. The orientation tuning of other regions of V2 appeared organized as modules that are larger and more uniform than those in V1.
引用
收藏
页码:417 / 420
页数:4
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