RETENTION BEHAVIOR AND CHIRAL RECOGNITION OF BETA-CYCLODEXTRIN-DERIVATIVE POLYMER ADSORBED ON SILICA FOR WARFARIN, STRUCTURALLY RELATED-COMPOUNDS AND DNS-AMINO ACIDS

被引：51

作者：

THUAUD, N

SEBILLE, B

DERATANI, A

LELIEVRE, G

机构：

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 555卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)87166-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Warfarin enantiomers that have previously been reported to be difficult to separate on cyclodextrin bonded high-performance liquid chromatographic supports can be easily and completely resolved on a stationary phase obtained by deposition on silica of an epichlorohydrin-beta-cyclodextrin polymer derivative. The separation of other hydroxy-coumarin analogues and Dns-amino acids is also demonstrated. Studying the influence of the pH and methanol content of the aqueous mobile phase allows the conditions required to separate these compounds to be optimized.

引用

收藏

页码：53 / 64

页数：12

相关论文

共 20 条

[1] SEPARATION OF METALLOCENE ENANTIOMERS BY LIQUID-CHROMATOGRAPHY - CHIRAL RECOGNITION VIA CYCLODEXTRIN BONDED PHASES [J].

ARMSTRONG, DW ;

DEMOND, W ;

CZECH, BP .

ANALYTICAL CHEMISTRY, 1985, 57 (02) :481-484

[2] SEPARATION OF DRUG STEREOISOMERS BY THE FORMATION OF BETA-CYCLODEXTRIN INCLUSION COMPLEXES [J].

ARMSTRONG, DW ;

WARD, TJ ;

ARMSTRONG, RD ;

BEESLEY, TE .

SCIENCE, 1986, 232 (4754) :1132-1135

[3] LIQUID-CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS CONTAINING SINGLE AROMATIC RINGS WITH BETA-CYCLODEXTRIN-BONDED PHASES [J].

ARMSTRONG, DW ;

HAN, YI ;

HAN, SM .

ANALYTICA CHIMICA ACTA, 1988, 208 (1-2) :275-281

[4] CHIRAL STATIONARY PHASES FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS - A MINI-REVIEW [J].

ARMSTRONG, DW .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1984, 7 :353-376

[5] 2-HYDROXY-3-TRIMETHYLAMMONIOPROPYL DERIVATIVES OF CYCLOMALTOHEPTAOSE AS PHASE-TRANSFER CATALYSTS [J].

DERATANI, A ;

LELIEVRE, G ;

MARALDO, T ;

SEBILLE, B .

CARBOHYDRATE RESEARCH, 1989, 192 :215-222

[6] RETENTION BEHAVIOR AND CHIRAL RECOGNITION MECHANISM OF SEVERAL CYCLODEXTRIN-BONDED STATIONARY PHASES FOR DANSYL AMINO-ACIDS [J].

FUJIMURA, K ;

SUZUKI, S ;

HAYASHI, K ;

MASUDA, S .

ANALYTICAL CHEMISTRY, 1990, 62 (20) :2198-2205

[7] INCLUSION OF AROMATIC-COMPOUNDS BY A BETA-CYCLODEXTRIN-EPICHLOROHYDRIN POLYMER [J].

HARADA, A ;

FURUE, M ;

NOZAKURA, S .

POLYMER JOURNAL, 1981, 13 (08) :777-781

[8] OPTICAL RESOLUTION OF MANDELIC-ACID DERIVATIVES BY COLUMN CHROMATOGRAPHY ON CROSSLINKED CYCLODEXTRIN GELS [J].

HARADA, A ;

FURUE, M ;

NOZAKURA, SI .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1978, 16 (01) :189-196

[9] LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS USING A CHIRAL BETA-CYCLODEXTRIN-BONDED STATIONARY PHASE AND CONVENTIONAL AQUEOUS ORGANIC MOBILE PHASES [J].

HINZE, WL ;

RIEHL, TE ;

ARMSTRONG, DW ;

DEMOND, W ;

ALAK, A ;

WARD, T .

ANALYTICAL CHEMISTRY, 1985, 57 (01) :237-242

[10]

HINZE WL, 1985, ANAL CHEM, V57, P239