A Statistical Method for Detecting Regions with Different Evolutionary Dynamics in Multialigned Sequences

被引：21

作者：

Pesole, G. ^{[1
]}

Attimonelli, M. ^{[1
]}

Preparata, G. ^{[2
]}

Saccone, C. ^{[1
]}

机构：

[1] Univ Bari, Dipartimento Biochim & Biol Mol, Bari, Italy

[2] Univ Milan, Dipartimento Fis, Milan, Italy

来源：

MOLECULAR PHYLOGENETICS AND EVOLUTION | 1992年 / 1卷 / 02期

关键词：

D O I：

10.1016/1055-7903(92)90023-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe a stochastic method for tracing the evolutionary pattern of multialigned sequences. This method allows us to detect gene regions with distinct evolutionary dynamics, e. g., regions that significantly deviate from the expected behavior. Accurate detection of hypervariable or hyperconstrained regions may provide useful information on the structure/function relationship of biosequences. This information can help localize functional constraints. In addition, the selection of distinct evolutionary dynamics may assist in the correct use of biosequences as reliable molecular clocks. (c) 1992 Academic Press, Inc.

引用

页码：91 / 96

页数：6

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