EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR AND ITS RECEPTOR IN THE RAT SUBFORNICAL ORGAN

被引：18

作者：

FRAUTSCHY, SA

GONZALEZ, AM

MURILLO, RM

CARCELLER, F

CUEVAS, P

BAIRD, A

机构：

[1] WHITTIER INST DIAB & ENDOCRINOL, DEPT MOLEC & CELLULAR GROWTH BIOL, 9894 GENESEE AVE, LA JOLLA, CA 92037 USA

[2] HOSP RAMON & CAJAL, SERV HISTOL, MADRID, SPAIN

来源：

NEUROENDOCRINOLOGY | 1991年 / 54卷 / 01期

关键词：

SUBFORNICAL ORGAN; BASIC FIBROBLAST GROWTH FACTOR; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; HYBRIDIZATION INSITU; IMMUNOHISTOCHEMISTRY;

D O I：

10.1159/000125852

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Basic fibroblast growth factor (FGF), its mRNA and the mRNA that encodes for its receptor have all been localized in the rat subfornical organ (SFO). Basic FGF is widely distributed throughout the SFO; it is present in neurons, in the vascular basement membrane of lateral blood vessels (but not those within the SFO) and in ependymal cells surrounding the SFO. Results of in situ hybridization show that the expression of basic FGF mRNA is detected throughout the organ. Similarly, the expression of flg, the gene for the putative basic FGF receptor, can also be detected in the SFO. The results all support the possibility that this growth factor may modulate the known physiological functions of the SFO.

引用

页码：62 / 67

页数：6

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