Role of transforming growth factor-beta (TGF) beta in the physiopathology of rheumatoid arthritis

被引：74

作者：

Gonzalo-Gil, Elena ^{[1
]}

Galindo-Izquierdo, Maria ^{[1
]}

机构：

[1] Lab Enfermedades Inflamatorias Autoinmune, Inst Investigat, 4+12,Hosp 12 Octubre, Madrid, Spain

来源：

REUMATOLOGIA CLINICA | 2014年 / 10卷 / 03期

关键词：

Rheumatoid artritis; Animal models; Collagen-induced arthritis; Transforming growth factor-beta; T cells;

D O I：

10.1016/j.reuma.2014.01.009

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Transforming growth factor-beta (TGF-beta) is a cytokine with pleiotropic functions in hematopoiesis, angiogenesis, cell proliferation, differentiation, migration and apoptosis. Although its role in rheumatoid arthritis is not well defined, TGF-beta activation leads to functional immunomodulatory effects according to environmental conditions. The function of TGF-beta in the development of arthritis in murine models has been extensively studied with controversial results. Recent findings point to a non-relevant role for TGF-beta in a mice model of collagen-induced arthritis. The study of TGF-beta on T-cell responses has shown controversial results as an inhibitor or promoter of the inflammatory response. This paper presents a review of the role of TGF-beta in animal models of arthritis. (C) 2013 Elsevier Espafia, S.L. All rights reserved.

引用

页码：174 / 179

页数：6

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