CONTROL OF AROMATASE IN BREAST-CANCER CELLS AND ITS IMPORTANCE FOR TUMOR-GROWTH

被引：44

作者：

DOWSETT, M

MACAULAY, V

GLEDHILL, J

RYDE, C

NICHOLLS, J

ASHWORTH, A

MCKINNA, JA

SMITH, IE

机构：

[1] INST CANC RES,CELL & MOLEC BIOL SECT,LONDON SW3 6JB,ENGLAND

[2] ROYAL MARSDEN HOSP,BREAST UNIT,LONDON SW3 6JJ,ENGLAND

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1993年 / 44卷 / 4-6期

关键词：

D O I：

10.1016/0960-0760(93)90266-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three approaches have been taken to elucidate further the biological importance of intratumoural aromatase activity. (i) MCF7 and T47D hormone-dependent breast cancer cell lines both showed detectable aromatase activity in vitro. The up-regulation of this by TGFalpha indicates the possible existence of an autocrine growth stimulatory loop involving aromatase. (ii) Both tamoxifen and cytotoxic chemotherapy caused the suppression of aromatase activity in breast carcinomas in vivo. Aromatase activity prior to treatment did not predict for clinical response to tamoxifen. (iii) Transfection of aromatase into MCF7 cells led to their growth being stimulated by low doses of androgens and this was inhibited by the aromatase inhibitor CGS 16949A.

引用

页码：605 / 609

页数：5

共 12 条

[1]

KATZENELLENBOGEN BS, 1987, CANCER RES, V47, P4355

[2] GROWTH-CONTROL OF NORMAL AND MALIGNANT BREAST EPITHELIUM [J].

LIPPMAN, ME ;

DICKSON, RB .

PROCEEDINGS OF THE ROYAL SOCIETY OF EDINBURGH SECTION B-BIOLOGICAL SCIENCES, 1989, 95 :89-106

[3]

LIPTON A, 1987, CANCER, V59, P779, DOI 10.1002/1097-0142(19870215)59:4<779::AID-CNCR2820590419>3.0.CO

[4]

2-U

[5]

MACAULAY VM, UNPUB BIOL EFFECTS S

[6] GROWTH-FACTORS SUPPRESS AND PHORBOL ESTERS POTENTIATE THE ACTION OF DIBUTYRYL ADENOSINE-3',5'-MONOPHOSPHATE TO STIMULATE AROMATASE-ACTIVITY OF HUMAN ADIPOSE STROMAL CELLS [J].

MENDELSON, CR ;

CORBIN, CJ ;

SMITH, ME ;

SMITH, J ;

SIMPSON, ER .

ENDOCRINOLOGY, 1986, 118 (03) :968-973

[7]

MILLER W R, 1987, Steroids, V50, P537, DOI 10.1016/0039-128X(87)90037-7

[8]

MILLER WR, 1974, BRIT J CANCER, V33, P16

[9]

MILLER WR, 1986, BREAST CANCER TREATM, P156

[10] INSITU ESTRONE SYNTHESIS IN NORMAL BREAST AND BREAST-TUMOR TISSUES - EFFECT OF TREATMENT WITH 4-HYDROXYANDROSTENEDIONE [J].

REED, MJ ;

OWEN, AM ;

LAI, LC ;

COLDHAM, NG ;

GHILCHIK, MW ;

SHAIKH, NA ;

JAMES, VHT .

INTERNATIONAL JOURNAL OF CANCER, 1989, 44 (02) :233-237

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