RISK-FACTORS FOR LATE-ONSET ALZHEIMERS-DISEASE - A POPULATION-BASED, CASE-CONTROL STUDY

被引:239
作者
FRATIGLIONI, L
AHLBOM, A
VIITANEN, M
WINBLAD, B
机构
[1] KAROLINSKA INST,DEPT GERIATR MED,S-10401 STOCKHOLM 60,SWEDEN
[2] KAROLINSKA INST,INST ENVIRONM MED,DEPT EPIDEMIOL,S-10401 STOCKHOLM 60,SWEDEN
关键词
D O I
10.1002/ana.410330306
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Our current knowledge of risk factors for Alzheimer's disease is limited and primarily addresses early-onset disease. This study aimed to determine the risk factors for late-onset Alzheimer's disease using a case-control approach. Ninety-eight cases and 216 controls were gathered from an ongoing population survey on aging and dementia in Stockholm (the Kungsholmen Project). We found a high relative risk (3.2; 95% confidence interval, 1.8-5.7) with the presence of at least one first-degree relative affected by dementia. Among all the other risk factors, alcohol abuse (relative risk, 4.4; 95% confidence interval, 1.4-13.8) and manual work (relative risk for men of 5.3; 95% confidence interval, 1.1-25.5) emerged as positively associated. No clear association was found with a family history of Parkinson disease, advanced parental age at index delivery, season of birth, or previous head trauma. In conclusion, our data suggest that the main risk factor for late-onset Alzheimer's disease is a family history of dementia, as has been previously reported for early-onset disease. Moreover, alcohol abuse and occupational exposure might play a specific role for this form of the disease.
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页码:258 / 266
页数:9
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共 61 条
  • [1] RISK-FACTORS FOR CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE - A CASE-CONTROL STUDY OF AN ITALIAN POPULATION
    AMADUCCI, LA
    FRATIGLIONI, L
    ROCCA, WA
    FIESCHI, C
    LIVREA, P
    PEDONE, D
    BRACCO, L
    LIPPI, A
    GANDOLFO, C
    BINO, G
    PRENCIPE, M
    BONATTI, ML
    GIROTTI, F
    CARELLA, F
    TAVOLATO, B
    FERLA, S
    LENZI, GL
    CAROLEI, A
    GAMBI, A
    GRIGOLETTO, F
    SCHOENBERG, BS
    [J]. NEUROLOGY, 1986, 36 (07) : 922 - 931
  • [2] THE INCIDENCE, CAUSES, AND SECULAR TRENDS OF HEAD TRAUMA IN OLMSTED-COUNTY, MINNESOTA, 1935-1974
    ANNEGERS, JF
    GRABOW, JD
    KURLAND, LT
    LAWS, ER
    [J]. NEUROLOGY, 1980, 30 (09) : 912 - 919
  • [3] AXELSON O, 1976, Scandinavian Journal of Work Environment and Health, V2, P14
  • [4] BLENNOW K, 1990, THESIS U GOTEBORG GO
  • [5] BREITNER JCS, 1988, NEUROLOGY, V38, P207
  • [6] FAMILIAL ALZHEIMER DEMENTIA - A PREVALENT DISORDER WITH SPECIFIC CLINICAL-FEATURES
    BREITNER, JCS
    FOLSTEIN, MF
    [J]. PSYCHOLOGICAL MEDICINE, 1984, 14 (01) : 63 - 80
  • [7] A CASE-CONTROL STUDY OF ALZHEIMERS-DISEASE IN AUSTRALIA
    BROE, GA
    HENDERSON, AS
    CREASEY, H
    MCCUSKER, E
    KORTEN, AE
    JORM, AF
    LONGLEY, W
    ANTHONY, JC
    [J]. NEUROLOGY, 1990, 40 (11) : 1698 - 1707
  • [8] CASE-CONTROL STUDY OF LATE ONSET PROBABLE ALZHEIMERS-DISEASE
    CHANDRA, V
    PHILIPOSE, V
    BELL, PA
    LAZAROFF, A
    SCHOENBERG, BS
    [J]. NEUROLOGY, 1987, 37 (08) : 1295 - 1300
  • [9] HEAD TRAUMA WITH LOSS OF CONSCIOUSNESS AS A RISK FACTOR FOR ALZHEIMERS-DISEASE
    CHANDRA, V
    KOKMEN, E
    SCHOENBERG, BS
    BEARD, CM
    [J]. NEUROLOGY, 1989, 39 (12) : 1576 - 1578
  • [10] CLINICAL SUBTYPES OF DEMENTIA OF THE ALZHEIMER TYPE
    CHUI, HC
    TENG, EL
    HENDERSON, VW
    MOY, AC
    [J]. NEUROLOGY, 1985, 35 (11) : 1544 - 1550