PRELIMINARY-REPORT ON A NEW COMPOSITE-MATERIAL MADE OF CALCIUM-PHOSPHATE, ELASTIN PEPTIDES AND COLLAGENS

With a view to elaborating a bioactive bone substitute, the association of an artificial extracellular matrix, basically constituted of elastin-solubilized peptides (ESP) and type I + III collagens, with different types of calcium phosphates, was investigated. This paper describes the selective adsorption of ESP on some calcium phosphate samples, and the further association of the adsorbed peptides with type I + III collagens. A preliminary study of the material cytotoxicity was carried out, investigating the behaviour of human osteoblast cells in contact with the yielded composite material.