2ND-TRIMESTER ABORTION BY INTRAMUSCULAR 15-METHYL-PROSTAGLANDIN F2-ALPHA OR INTRAVAGINAL PROSTAGLANDIN E(2) SUPPOSITORIES - A RANDOMIZED TRIAL

被引：19

作者：

BORGIDA, AF ^{[1
]}

RODIS, JF ^{[1
]}

HANLON, W ^{[1
]}

CRAFFEY, A ^{[1
]}

CIARLEGLIO, L ^{[1
]}

CAMPBELL, WA ^{[1
]}

机构：

[1] UNIV CONNECTICUT,CTR HLTH,DEPT PEDIAT,DIV HUMAN GENET,FARMINGTON,CT 06032

来源：

OBSTETRICS AND GYNECOLOGY | 1995年 / 85卷 / 05期

关键词：

D O I：

10.1016/0029-7844(95)00011-F

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To compare intramuscular (IM) prostaglandin 15 methyl-F-2 alpha (15M-PGF(2 alpha)) with prostaglandin E(2) (PGE(2)) vaginal suppositories for second-trimester abortion in terms of efficacy and side effects. Methods: Fifty-one women were randomized to receive either 15M-PGF(2 alpha) IM injections or PGE(2) intravaginal suppositories for second-trimester abortion. Efficacy and side effects of the two agents were analyzed by two-tailed t tests, chi(2) analysis with Fisher exact test, and survival analysis. Results: The mean times to rupture of membranes, delivery of fetus, and delivery of placenta were significantly less for women receiving PGE(2) vaginal suppositories. The cumulative abortion rate after 24 hours for the PGE(2) group was 96%, compared with 69% for the 15M-PGF(2 alpha) group. Although there were few differences in side effects, the 15M-PGF(2 alpha) group had significantly fewer headaches, fevers, and chills. Conclusion: Intravaginal PGE(2) is superior to IM 15M-PGF(2 alpha) for second-trimester abortion.

引用

页码：697 / 700

页数：4

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