A 2ND EWINGS-SARCOMA TRANSLOCATION, T(2122), FUSES THE EWS GENE TO ANOTHER ETS-FAMILY TRANSCRIPTION FACTOR, ERG

被引：620

作者：

SORENSEN, PHB

LESSNICK, SL

LOPEZTERRADA, D

LIU, XF

TRICHE, TJ

DENNY, CT

机构：

[1] UNIV SO CALIF,CHILDRENS HOSP LOS ANGELES,DEPT PATHOL & LAB MED,LOS ANGELES,CA 90027

[2] UNIV CALIF LOS ANGELES,DEPT PEDIAT,GWYNNE HAZEN CHERRY MEM LABS,DIV HEMATOL ONCOL,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,JONSSON COMPREHENS CANC CTR,LOS ANGELES,CA 90024

来源：

NATURE GENETICS | 1994年 / 6卷 / 02期

关键词：

D O I：

10.1038/ng0294-146

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The t(11;22)(q24;q12), present in 85% of Ewing's sarcoma and related tumours, fuses the EWS gene from chromosome 22q12 and the ETS family member, FLI-1 This results in the expression of a chimaeric protein containing the amino-terminal portion of EWS fused to the ETS DNA-binding domain of FLI-1. We have identified a second Ewing's sarcoma translocation, t(21;22)(q22;q12), that fuses EWS to a different ETS family member, the ERG gene located on band 21q22. Identical EWS nucleotide sequences found in the EWS/FLI-1 fusion transcripts are fused to portions of ERG encoding an ETS DNA-binding domain resulting in expression of a hybrid EWS/ERG protein. These findings suggest that fusion of EWS to different members of the ETS family of transcription factor genes may result in the expression of similar disease phenotypes.

引用

页码：146 / 151

页数：6

共 29 条

[1] ERYTHROLEUKEMIA INDUCTION BY FRIEND MURINE LEUKEMIA-VIRUS - INSERTIONAL ACTIVATION OF A NEW MEMBER OF THE ETS GENE FAMILY, FLI-1, CLOSELY LINKED TO C-ETS-1 [J].