DISTRIBUTION OF ENTERIC NEURAL PEPTIDE YY IN THE DOG GASTROINTESTINAL-TRACT

被引：8

作者：

IESAKI, K

SAKAI, T

SATOH, M

HAGA, N

KOYAMA, H

ITOH, Z

机构：

[1] GUNMA UNIV,INST MOLEC & CELLULAR REGULAT,GASTROINTESTINAL RES LABS,MAEBASHI,GUMMA 371,JAPAN

[2] SAITAMA UNIV,FAC SCI,DEPT REGULAT BIOL,URAWA,SAITAMA 338,JAPAN

来源：

PEPTIDES | 1995年 / 16卷 / 08期

关键词：

PEPTIDE YY (PYY); DOG; CHOLINE ACETYLTRANSFERASE (CHAT); MYENTERIC PLEXUS; IMMUNOCYTOCHEMISTRY; RADIOIMMUNOASSAY (RIA); NONCHOLINERGIC ENTERIC NEURONS;

D O I：

10.1016/0196-9781(95)02031-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various regions of the dog gastrointestinal tract were investigated for the distribution of peptide YY (PYY) neurons using immunocytochemistry and radioimmunoassay. PYY neurons that encircled non-PYY-immunoreactive neurons were mainly observed in the myenteric plexus from the stomach to the colon. There was more PYY-like immunoreactivity in the muscle layer of the stomach and ileum than in the other intestines. The results of high performance liquid chromatography revealed that neural PYY-immunoreactive substance is identical to authentic PYY. PYY was not localized in the cholinergic neurons. These results indicate that PYY, as a neuropeptide, is involved in the regulation of gastrointestinal function.

引用

页码：1395 / 1402

页数：8

共 44 条

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