PULMONARY-DISEASE AND ANTIPYRINE CLEARANCE

被引:22
作者
LAYBOURN, C
TONNESEN, P
LOFT, S
SONNE, J
DOSSING, M
机构
[1] BISPEBJERG HOSP, DEPT MED P, 23 BISPEBJERG BAKKE, DK-2400 COPENHAGEN NV, DENMARK
[2] LYNGBY LUNG CLIN, LYNGBY, DENMARK
[3] BISPEBJERG HOSP, LUNG CLIN, DK-2400 COPENHAGEN NV, DENMARK
[4] UNIV COPENHAGEN, GENTOFTE HOSP, DEPT MED F, DK-1168 COPENHAGEN, DENMARK
关键词
D O I
10.1038/clpt.1986.199
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We investigated hepatic microsomal enzyme activity by the one-sample saliva test for antipyrine clearance determination in 35 homozygous, .alpha.1-antitrypsin-deficient outpatients with chronic pulmonary disease. Twenty-five outpatients with chronic obstructive lung disease and comparable lung function impairment and 31 healthy volunteers served as controls. Antipyrine clearance did not differ significantly between the two groups of patients with pulmonary disease. However, the clearance was 18% lower in these two groups than in the healthy volunteers (P < 0.01). Antipyrine clearance was lowest in patients with severe lung function impairment (P < 0.01).
引用
收藏
页码:415 / 419
页数:5
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