ANTI-MALARIALS .4. TRICHLORONAPHTHALENE AMINO-ALCOHOLS

被引：8

作者：

SHAMBLEE, DA ^{[1
]}

GILLESPIE, JS ^{[1
]}

机构：

[1] UNIV RICHMOND,DEPT CHEM,RICHMOND,VA 23173

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 01期

关键词：

D O I：

10.1021/jm00187a019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An improved procedure for the synthesis of naphthalene amino alcohols is described. Four new compounds were prepared and tested by Rane Laboratories for activity vs. Plasmodium berghei in mice. All compounds were active, the most active being l-[3-(4-chlorophenyl)-5.7-dichloro-l-naphthyl]-3-(di-n-butylamino)propanol hydrochloride(16b). Structure-activity relationships between the naphthalene and quinoline isosteres are discussed. © 1979, American Chemical Society. All rights reserved.

引用

页码：86 / 89

页数：4

共 8 条

[1] BASE-INDUCED REACTION OF ORGANOBORANES WITH BROMINE - A CONVENIENT PROCEDURE FOR ANTI-MARKOVNIKOV HYDROBROMINATION OF TERMINAL OLEFINS VIA HYDROBORATION-BROMINATION [J].