LOCATION OF THE SUPRACHIASMATIC NUCLEUS GRAFTS IN RATS WHICH RESTORED CIRCADIAN RHYTHMICITY AFTER TRANSPLANTATION

被引：15

作者：

SAITOH, Y

NIHONMATSU, I

KAWAMURA, H

机构：

[1] Mitsubishi Kasei Institute of Life Sciences, Machida-shi, Tokyo

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 01期

关键词：

Circadian rhythm; Suprachiasmatic nucleus; Third ventricle; Transplantation; Wheel running;

D O I：

10.1016/0304-3940(90)90245-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Wistar male rats whose circadian wheel running activity rhythms were disrupted by bilateral suprachiasmatic nuclei (SCN) lesions, transplantation of neonatal rat SCN into the 3rd ventricle was performed. Out of 49 rats from which adequate wheel running activity records were obtained, 15 rats showed restoration of circadian rhythm starting 2 to 13 weeks (average 1 month) after transplantation. The existence of active SCN neurons in the graft was shown by immunocytochemical reactivity to vasopressin- and VIP-like substances. In all rats, effective grafts were found in the diencephalon, mostly on the wall of the 3rd ventricle. © 1990.

引用

页码：45 / 48

页数：4

共 12 条

[1] AN AUTORADIOGRAPHIC DETERMINATION OF THE EFFERENT PROJECTIONS OF THE SUPRACHIASMATIC NUCLEUS OF THE HYPOTHALAMUS [J].