GLUCURONIDATION OF 3-ALPHA-HYDROXYSTEROIDS INVITRO

被引：4

作者：

CARLSON, GL ^{[1
]}

MATTOX, VR ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,ROCHESTER,MN 55901

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1979年 / 10卷 / 02期

关键词：

D O I：

10.1016/0022-4731(79)90230-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the presence of UDP-glucuronic acid and UDP-glucuronyltransferase, steroids with the 3α-hydroxy-5β-pregnane structure was converted into the corresponding C-3 β-D-glucosiduronates in 60-98%a yield, those with the 3α-hydroxy-5α-pregnane structure give yields of 20-30% and those of the 3β-hydroxy-5α series are not conjugated. Aldosterone, corticosterone and cortisone are inert toward conjugation. The conjugating procedure has been used to prepare steroidal glucosiduronates of high S.A. from tritiumlabeled 3α-hydroxy-5β-pregnanes. © 1979.

引用

页码：161 / 165

页数：5

共 13 条

[1] ISOLATION OF TETRAHYDROALDOSTERONE 3 BETA-GLUCOSIDURONIC ACID FROM URINE [J].