PRELIMINARY-RESULTS OF A PILOT-STUDY OF PENTOXIFYLLINE IN THE TREATMENT OF LATE RADIATION SOFT-TISSUE NECROSIS

被引：120

作者：

DION, MW ^{[1
]}

HUSSEY, DH ^{[1
]}

DOORNBOS, JF ^{[1
]}

VIGLIOTTI, AP ^{[1
]}

WEN, BC ^{[1
]}

ANDERSON, B ^{[1
]}

机构：

[1] UNIV IOWA,COLL MED,IOWA CITY,IA 52242

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 19卷 / 02期

关键词：

Late radiation injury; Pentoxifylline; Radiation therapy; Radiation therapy complications;

D O I：

10.1016/0360-3016(90)90549-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Between September 1988 and August 1989, 12 patients with 15 sites of late radiation necrosis of the soft tissues were treated with pentoxifylline, a hemorrheologic agent that has been used to treat a variety of vascuao-occlusive disorders. Four of these necroses were located in the oromucosa, four in the mucosa of the female genitalia, and seven in the skin. At the time of analysis, 87% ( 13 15) of the necroses had healed completely, and one was partially healed. Furthermore, the time-course of healing with pentoxifylline was significantly less than the duration of nonhealing prior to pentoxifylline (average: 9 weeks vs 30 1 2 weeks). All patients had pain relief. These results indicate that pentoxifylline can contribute to the healing of soft tissue radiation necrosis. They also support the concept that late radiation injury in skin and mucosa is at least partly due to vascular injury. © 1990.

引用

页码：401 / 407

页数：7

共 26 条

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