EPONEMYCIN, A NEW ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA .1. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY

被引：78

作者：

SUGAWARA, K

HATORI, M

NISHIYAMA, Y

TOMITA, K

KAMEI, H

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Meguro-ku, Tokyo 153

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 01期

关键词：

D O I：

10.7164/antibiotics.43.8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces hygroscopicus No. P247-71 (ATCC 53709) produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L-serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：8 / 18

页数：11