EPONEMYCIN, A NEW ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA .1. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY

被引:78
作者
SUGAWARA, K
HATORI, M
NISHIYAMA, Y
TOMITA, K
KAMEI, H
KONISHI, M
OKI, T
机构
[1] Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Meguro-ku, Tokyo 153
关键词
D O I
10.7164/antibiotics.43.8
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Streptomyces hygroscopicus No. P247-71 (ATCC 53709) produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L-serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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页码:8 / 18
页数:11
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