THE HUMAN GLUTATHIONE S-TRANSFERASES - A CASE-CONTROL STUDY OF THE INCIDENCE OF THE GST1-0 PHENOTYPE IN PATIENTS WITH ADENOCARCINOMA

被引：173

作者：

STRANGE, RC ^{[1
]}

MATHAROO, B ^{[1
]}

FAULDER, GC ^{[1
]}

JONES, P ^{[1
]}

COTTON, W ^{[1
]}

ELDER, JB ^{[1
]}

DEAKIN, M ^{[1
]}

机构：

[1] UNIV KEELE, DEPT MATH, KEELE ST5 5BG, STAFFS, ENGLAND

来源：

CARCINOGENESIS | 1991年 / 12卷 / 01期

关键词：

D O I：

10.1093/carcin/12.1.25

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The suggestion that individuals with the GST1 0 phenotype have a greater susceptibility to carcinogens than those with other GST1 phenotypes has been examined by using a starch gel zymogram approach to compare the frequency of this phenotype in control subjects and a group of patients with adenocarcinoma of stomach and colon. A significantly greater proportion of the patients with adenocarcinoma demonstrated the null phenotype, odds ratio analysis indicating that individuals with this polymorphic variant have an approximately 3-fold greater risk of developing these cancers.

引用

页码：25 / 28

页数：4

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