PLASMA-RENIN ACTIVITY, ANGIOTENSIN-II, PROSTACYCLIN AND THROMBOXANE-A2 CONCENTRATIONS IN 139 PREECLAMPTIC PATIENTS

被引：12

作者：

FURUHASHI, N ^{[1
]}

TSUJIEI, M ^{[1
]}

KIMURA, H ^{[1
]}

YAJIMA, A ^{[1
]}

KIMURA, C ^{[1
]}

IDE, Y ^{[1
]}

机构：

[1] MIYAKO HOSP, MIYAKO 027, JAPAN

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 162卷 / 03期

关键词：

PLASMA RENIN ACTIVITY; ANGIOTENSIN-II; PROSTACYCLIN; THROMBOXANE-A2; PREECLAMPSIA;

D O I：

10.1620/tjem.162.235

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma renin activity, plasma concentrations of angiotensin ll (AngII), stable metabolites (6-keto-prostaglandin F1a: 6-keto-PGF1a) of prostacyclin (PGI2) and a metabolite (thromboxane B2: TXB2) of thromboxane A2 (TXA2) were measured with radioimmunoassay(RIA) in 107 normal pregnancy (control) and 139 preeclamptic patients in 28-41 gestational weeks. PRA and 6-keto-PGF1a were significantly higher and AngII was slightly higher in preeclampsia than in control, and TXB2 was significantly lower in preeclampsia in control. The ratio of 6-keto-PGF1-alpha/TXB2 was significantly lower in preeclampsia than in control. These data suggest that the changes in the renin-angiotensin system may not be primary alterations in preeclampsia. It can be speculated that in preeclampsia the changes in absolute concentrations of 6-keto-PGF1-alpha and TXB2 are less important than the decrease in the ratio of the 6-keto-PGF1-alpha/TXB2.

引用

页码：235 / 241

页数：7

共 27 条

[1] DOWNING I, 1980, LANCET, V2, P1374
[2] EVERETT RB, 1978, SEMIN PERINATOL, V2, P3
[3] FRIEDMAN SA, 1988, OBSTET GYNECOL, V71, P122
[4] GANT N, 1976, HYPERTENS PREGNANCY, P11
[5] GORDON RD, 1969, LANCET, V1, P347
[6] PLASMA-RENIN ACTIVITY, PLASMA ANGIOTENSIN AND PLASMA AND URINARY ELECTROLYTES IN NORMAL AND TOXEMIC PREGNANCY, INCLUDING A PROSPECTIVE STUDY
GORDON, RD
SYMONDS, EM
WILMSHURST, EG
PAWSEY, CGK
[J]. CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1973, 45 (01): : 115 - 127
[7] MEASUREMENT OF PLASMA-RENIN ACTIVITY BY A SIMPLE SOLID-PHASE RADIOIMMUNOASSAY
IKEDA, I
IINUMA, K
TAKAI, M
YANAGAWA, Y
KURATA, K
OGIHARA, T
KUMAHARA, Y
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1982, 54 (02) : 423 - 428
[8] SENSITIVE RADIOIMMUNOASSAY FOR THE DETERMINATION OF PLASMA ANGIOTENSIN-II IN HUMAN-SUBJECTS
KOBAYASHI, H
SHIMAMOTO, K
MORIGUCHI, O
MIYAHARA, M
[J]. JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1979, 43 (08): : 727 - 733
[9] PLASMA PROSTANOIDS IN PREGNANCY-INDUCED HYPERTENSION
KOULLAPIS, EN
NICOLAIDES, KH
COLLINS, WP
RODECK, CH
CAMPBELL, S
[J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1982, 89 (08): : 617 - 621
[10] LEWIS PJ, 1983, PROSTACYCLIN PREGNAN, P215

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