THE HUMAN HOMOLOG OF THE MOUSE COMMON VIRAL INTEGRATION REGION, FLI1, MAPS TO 11Q23-Q24

被引：20

作者：

BAUD, V

LIPINSKI, M

RASSART, E

POLIQUIN, L

BERGERON, D

机构：

[1] INST GUSTAVE ROUSSY,BIOL TUMEURS LAB,CNRS,URA 1156,RUE CAMILLE DESMOULINS,F-94805 VILLEJUIF,FRANCE

[2] UNIV QUEBEC,DEPT SCI BIOL,BIOL MOLEC LAB,MONTREAL H3C 38P,QUEBEC,CANADA

来源：

GENOMICS | 1991年 / 11卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(91)90124-W

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

FLI1 is a common mouse viral integration region in virus-induced leukemias and lymphomas. Using an evolutionarily conserved mouse probe and Southern hybridization to (rodent × human) somatic cell hybrid DNAs, the human homolog of FLI1 has been shown to lie on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint. © 1991.

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页码：223 / 224

页数：2

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