GA-67 9N3 UPTAKE BY XENOGRAFTS OF HUMAN MELANOTIC MELANOMA IN MICE

被引：9

作者：

HARRISON, A

WALKER, CA

PEREIRA, KA

PARKER, D

ROYLE, L

MATTHEWS, RC

CRAIG, AS

机构：

[1] Medical Research Council, Radiobiology Unit, Chilton, Didcot, Oxon

[2] University of Durham, Department of Chemistry, Durham, DH1 3LE, South Road

[3] MRC Radiobiology Unit, Chilton, Didcot, Oxon

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1992年 / 13卷 / 09期

关键词：

D O I：

10.1097/00006231-199209000-00006

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Tumour uptake of the inert, neutral CoMpleX Ga-67-9N3 and the tumour:blood concentration ratio (1,4,7,triazacyclononane-1,4,7, triacetic acid) were measured in mice bearing xenografts of the human melanotic melanoma HX118. Between 1 and 4 h after the injection the tumour:blood ratio increased from 3.5 to 21 and the concentration of Ga-67-9N3 in the tumour decreased from 0.43 to 0.13% g-1. During the first 24 h the concentration of Ga-67-9N3 in the tumour exceeded that in all other tissues except the liver and kidneys. The tumour:blood ratio and tissue distribution of Ga-67-9N3 at 4 h were compared with those of four other complexes. The results indicated that of the five complexes Ga-67-9N3 would be the most suitable for tumour imaging at early times after administration. Imaging would not be restricted to gamma-emitting Ga-67 as there is also the possibility of using the 9N3 ligand to bind ln-111 for single photon emission computed tomography (SPECT), Ga-68 for positron emission tomography (PET) or even stable Ga for direct in vivo nuclear magnetic resonance (NMR) detection.

引用

页码：667 / 672

页数：6

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