SEROTONERGIC DYSFUNCTION IN DEPRESSION ASSOCIATED WITH PARKINSONS-DISEASE

被引：66

作者：

MCCANCEKATZ, EF ^{[1
]}

MAREK, KL ^{[1
]}

PRICE, LH ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,NATL PARKINSON FDN LAB CLIN & THERAPEUT SERV,NEW HAVEN,CT 06508

来源：

NEUROLOGY | 1992年 / 42卷 / 09期

关键词：

D O I：

10.1212/WNL.42.9.1813

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 55-year-old man presented with a 5-year history of Parkinson's disease and a 6-month history of major depression. The patient's depressive symptoms responded to treatment with fluvoxamine, a selective and potent serotonin reuptake inhibitor. Tryptophan depletion testing, which acutely lowers central serotonin levels, caused a brief exacerbation of the depressive illness, which resolved upon tryptophan repletion. Serotonergic dysfunction may be an etiologic factor in depression that occurs in Parkinson's disease.

引用

页码：1813 / 1814

页数：2

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