STRUCTURE OF THE SEQUENCES ADJACENT TO THE CENTROMERIC ALPHOID SATELLITE DNA ARRAY ON THE HUMAN Y-CHROMOSOME

被引：56

作者：

COOPER, KF ^{[1
]}

FISHER, RB ^{[1
]}

TYLERSMITH, C ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT BIOCHEM,CRC,CHROMOSOME MOLEC BIOL GRP,S PARKS RD,OXFORD OX1 3QU,ENGLAND

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1993年 / 230卷 / 03期

关键词：

HUMAN Y-CHROMOSOME; CENTROMERE; SATELLITE DNAS; YACS;

D O I：

10.1006/jmbi.1993.1201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eighteen yeast artificial chromosome (YAC) clones containing alphoid satellite DNA and adjacent sequences from the human Y chromosome have been identified from three different YAC libraries. Restriction site mapping of the genomic alphoid arrays and the YACs has allowed seven of the alphoid clones to be positioned on the arrays. Three clones extend into flanking sequences. At one edge the alphoid DNA is highly diverged and is flanked by a small block of the 48 base-pair satellite, dispersed moderately repeated sequences and a separate short alphoid array. More distal sequences are Y-specific. At the other edge there is much less divergence and the alphoid DNA is flanked by an Alu sequence and the five base-pair satellite. © 1993 Academic Press, Inc.

引用

页码：787 / 799

页数：13

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