SUBCELLULAR-LOCALIZATION OF TAU-MESSENGER RNA IN DIFFERENTIATING NEURONAL CELL-CULTURE - IMPLICATIONS FOR NEURONAL POLARITY

被引:159
作者
LITMAN, P
BARG, J
RINDZOONSKI, L
GINZBURG, I
机构
[1] Department of Neurobiology The Weizmann Institute of Science
基金
俄罗斯基础研究基金会;
关键词
D O I
10.1016/0896-6273(93)90165-N
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A primary neuronal cell culture derived from whole brains of fetal rats was used to analyze the subcellular localization of tau mRNA, employing nonisotopic detection by in situ hybridization. The culture exhibited a developmental differentiation pattern previously described for neuronal cells in vivo; i.e., a transition from immature to mature tau isoforms as well as segregation of tau into the axons. Our results demonstrate that unlike tubulin mRNA, which is confined to cell bodies, or MAP2 mRNA, which extends into dendrites, tau mRNA was observed to enter the proximal portion of the axon. This sorting of tau mRNA might explain how the tau protein could be selectively delivered to the axon and could have important implications for the development of neuronal polarity.
引用
收藏
页码:627 / 638
页数:12
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