Based on lithological, structural and geophysical characteristics, the Proterozoic Grenville Orogen of southern Ontario and New York has been divided into domains that are separated from each other by ductile shear zones. In order to constrain the timing of metamorphism, U-Pb ages were determined on metamorphic and igneous sphenes from marbles, calc-silicate gneisses, amphibolites, granitoids, skarns and pegmatites. In addition, U-Pb ages were obtained for monazites from metapelites and for a rutile from an amphibolite. These mineral ages constrain the timing of mineral growth, the duration of metamorphism and the cooling history of the different domains that make up the southern part of the exposed Grenville Orogen. Based on the ages from metamorphic minerals, regional and contact metamorphism occurred in the following intervals: [GRAPHICS] Combination of mineral ages with results from thermobarometry indicates that metamorphic pressures and temperatures recorded by thermobarometers were reached polychronously in the different domains that are separated by major shear zones. Some of these shear zones such as the Robertson Lake shear zone and the Carthage-Colton shear zone represent major tectonic boundaries. The Grenville Orogen is made up of a collage of crustal terranes that have distinct thermal and tectonic histories and that were accreted laterally by tectonic processes analogous to those observed along modern active continental margins. The subsequent history of the orogen is characterized by slow time-integrated cooling rates of 3 +/- 1-degrees-C/Ma and denudation rates of 120 +/- 40 m/Ma.