STUDIES ON MORPHOLINOSPHINGOLIPIDS - POTENT INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE

被引：41

作者：

CARSON, KG

GANEM, B

RADIN, NS

ABE, A

SHAYMAN, JA

机构：

[1] CORNELL UNIV,DEPT CHEM,BAKER LAB,ITHACA,NY 14853

[2] UNIV MICHIGAN,DEPT INTERNAL MED,DIV NEPHROL,ANN ARBOR,MI 48109

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)76999-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic 1-morpholino-1-deoxyceramides were designed to inhibit glucosylceramide synthase. The most potent inhibitor 2a possesses the unnatural R,R-configuration of D-threo-sphingosine.

引用

页码：2659 / 2662

页数：4

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