THE P-BROMOBENZAMIDO CHROMOPHORE AS A CIRCULAR DICHROIC PROBE FOR THE ASSIGNMENT OF THE SCREW SENSE OF HELICAL PEPTIDES

被引：40

作者：

TONIOLO, C ^{[1
]}

FORMAGGIO, F ^{[1
]}

CRISMA, M ^{[1
]}

SCHOEMAKER, HE ^{[1
]}

KAMPHUIS, J ^{[1
]}

机构：

[1] DSM RES BV,BIOORGAN CHEM SECT,6160 MD GELEEN,NETHERLANDS

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 04期

关键词：

D O I：

10.1016/0957-4166(94)80004-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The para-bromobenzoyl group linked to the N-terminus of a helical peptide chain turned out to be useful as a CD probe in the determination of the relationship between C-alpha-configuration of coded and non-coded alpha-amino acids and peptide helix screw sense in solution. The results of the present conformational investigation agree well with published crystal-state structural data on the same peptides obtained using X-ray diffraction where the para-bromobenzoyl group helped us to solve the phase problem by virtue of its heavy atom (bromine).

引用

页码：507 / 510

页数：4

共 23 条

[1]

AUBRY A, 1994, IN PRESS J CHEM S P2

[2] LONG, CHIRAL POLYPEPTIDE-310- HELICES AT ATOMIC RESOLUTION [J].

BAVOSO, A ;

BENEDETTI, E ;

DIBLASIO, B ;

PAVONE, V ;

PEDONE, C ;

TONIOLO, C ;

BONORA, GM ;

FORMAGGIO, F ;

CRISMA, M .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1988, 5 (04) :803-817

[3]

CRISMA M, 1992, GAZZ CHIM ITAL, V122, P239

[4] STRUCTURAL CHARACTERIZATION OF THE BETA-BEND RIBBON SPIRAL - CRYSTALLOGRAPHIC ANALYSIS OF 2 LONG (L-PRO-AIB)N SEQUENTIAL PEPTIDES [J].

DIBLASIO, B ;

PAVONE, V ;

SAVIANO, M ;

LOMBARDI, A ;

NASTRI, F ;

PEDONE, C ;

BENEDETTI, E ;

CRISMA, M ;

ANZOLIN, M ;

TONIOLO, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (16) :6273-6278

[5] LINEAR OLIGOPEPTIDES .275. REVERSE RELATIONSHIP BETWEEN ALPHA-CARBON CHIRALITY AND HELIX HANDEDNESS IN (ALPHA-ME)PHE PEPTIDES [J].

FORMAGGIO, F ;

PEGORARO, S ;

CRISMA, M ;

VALLE, G ;

TONIOLO, C ;

PRECIGOUX, G ;

BOESTEN, WHJ ;

SCHOEMAKER, HE ;

KAMPHUIS, J .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1993, 10 (05) :919-931

[6] CONFORMATIONAL STUDIES OF PROTEINS WITH AROMATIC SIDE-CHAIN EFFECTS [J].

GOODMAN, M ;

TONIOLO, C .

BIOPOLYMERS, 1968, 6 (12) :1673-&

[7]

Harada N., 1983, CIRCULAR DICHROIC SP

[8]

KAWAI M, 1975, TETRAHEDRON LETT, P3165

[9] SYNTHESIS OF OPTICALLY PURE ALPHA-ALKYLATED ALPHA-AMINO-ACIDS AND A SINGLE-STEP METHOD FOR ENANTIOMERIC EXCESS DETERMINATION [J].

KRUIZINGA, WH ;

BOLSTER, J ;

KELLOGG, RM ;

KAMPHUIS, J ;

BOESTEN, WHJ ;

MEIJER, EM ;

SCHOEMAKER, HE .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (08) :1826-1827

[10] CIRCULAR DICHROIC STUDIES OF 2-AMINO-2-DEOXY-GALACTOPYRANOSIDES - CONFORMATIONS OF THE 2-(N-ACETYL-P-BROMOBENZAMIDO) GROUP [J].

LO, LC ;

BEROVA, N ;

NAKANISHI, K ;

MORALES, EQ ;

VAZQUEZ, JT .

TETRAHEDRON-ASYMMETRY, 1993, 4 (03) :321-330

← 1 2 3 →