SEARCHING FOR COMPLEX DISEASE GENES - CAN IT BE MADE ANY EASIER

被引：5

作者：

BARON, M

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT,NEW YORK,NY 10032

[2] NEW YORK STATE PSYCHIAT INST & HOSP,DEPT MED GENET,NEW YORK,NY 10032

来源：

PSYCHIATRIC GENETICS | 1995年 / 5卷 / 02期

关键词：

COMPLEX DISEASE; GENE MAPPING; PSYCHIATRIC DISORDERS;

D O I：

10.1097/00041444-199522000-00007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The search for complex disease genes is gaining momentum. Recent guidelines for expediting this effort, such as ''intelligent'' genome scanning and statistical criteria for detecting weak signals indicative of linkage, are discussed, with special reference to psychiatric disorders.

引用

收藏

页码：89 / 91

页数：3

相关论文

共 26 条

[1] GENOME LINKAGE SCANNING - SYSTEMATIC OR INTELLIGENT [J].

ANTONARAKIS, SE .

NATURE GENETICS, 1994, 8 (03) :211-212

[2] MATERNALLY TRANSMITTED DIABETES AND DEAFNESS ASSOCIATED WITH A 10.4 KB MITOCHONDRIAL-DNA DELETION [J].

BALLINGER, SW ;

SHOFFNER, JM ;

HEDAYA, EV ;

TROUNCE, I ;

POLAK, MA ;

KOONTZ, DA ;

WALLACE, DC .

NATURE GENETICS, 1992, 1 (01) :11-15

[3] DIMINISHED SUPPORT FOR LINKAGE BETWEEN MANIC-DEPRESSIVE ILLNESS AND X-CHROMOSOME MARKERS IN 3 ISRAELI PEDIGREES [J].

BARON, M ;

FREIMER, NF ;

RISCH, N ;

LERER, B ;

ALEXANDER, JR ;

STRAUB, RE ;

ASOKAN, S ;

DAS, K ;

PETERSON, A ;

AMOS, J ;

ENDICOTT, J ;

OTT, J ;

GILLIAM, TC .

NATURE GENETICS, 1993, 3 (01) :49-55

[4] NOVEL STRATEGIES IN MOLECULAR-GENETICS OF MENTAL-ILLNESS [J].

BARON, M .

BIOLOGICAL PSYCHIATRY, 1994, 35 (10) :757-760

[5]

BARON M, 1995, IN PRESS ACTA PSYCHI

[6] THE DISTRIBUTION OF CPG ISLANDS IN MAMMALIAN CHROMOSOMES [J].

CRAIG, JM ;

BICKMORE, WA .

NATURE GENETICS, 1994, 7 (03) :376-382

[7]

CROWE RR, 1993, AM J MED GENET, V48, P76

[8] A GENOME-WIDE SEARCH FOR HUMAN TYPE-1 DIABETES SUSCEPTIBILITY GENES [J].

DAVIES, JL ;

KAWAGUCHI, Y ;

BENNETT, ST ;

COPEMAN, JB ;

CORDELL, HJ ;

PRITCHARD, LE ;

REED, PW ;

GOUGH, SCL ;

JENKINS, SC ;

PALMER, SM ;

BALFOUR, KM ;

ROWE, BR ;

FARRALL, M ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE, 1994, 371 (6493) :130-136

[9] CAUTION IN LOCATING THE GENE(S) FOR AFFECTIVE-DISORDER [J].

EDWARDS, JH ;

WATT, DC .

PSYCHOLOGICAL MEDICINE, 1989, 19 (02) :273-275

[10] A LOCUS ON CHROMOSOME 15Q26 (IDDM3) PRODUCES SUSCEPTIBILITY TO INSULIN-DEPENDENT DIABETES-MELLITUS [J].

FIELD, LL ;

TOBIAS, R ;

MAGNUS, T .

NATURE GENETICS, 1994, 8 (02) :189-194