FAMILIAL DEFICIENCY OF DIHYDROPYRIMIDINE DEHYDROGENASE - BIOCHEMICAL BASIS FOR FAMILIAL PYRIMIDINEMIA AND SEVERE 5-FLUOROURACIL-INDUCED TOXICITY

被引：425

作者：

DIASIO, RB ^{[1
]}

BEAVERS, TL ^{[1
]}

CARPENTER, JT ^{[1
]}

机构：

[1] UNIV ALABAMA, CTR COMPREHENS CANC, DIV HEMATOL & ONCOL, BIRMINGHAM, AL 35294 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1988年 / 81卷 / 01期

关键词：

D O I：

10.1172/JCI113308

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：47 / 51

页数：5

共 15 条

[1] ELEVATED URINE, BLOOD AND CEREBROSPINAL-FLUID LEVELS OF URACIL AND THYMINE IN A CHILD WITH DIHYDROTHYMINE DEHYDROGENASE-DEFICIENCY [J].

BAKKEREN, JAJM ;

DEABREU, RA ;

SENGERS, RCA ;

GABREELS, FJM ;

MAAS, JM ;

RENIER, WO .

CLINICA CHIMICA ACTA, 1984, 140 (03) :247-256

[2] DIHYDROPYRIMIDINE DEHYDROGENASE-DEFICIENCY LEADING TO THYMINE-URACILURIA - AN INBORN ERROR OF PYRIMIDINE METABOLISM [J].

BERGER, R ;

STOKERDEVRIES, SA ;

WADMAN, SK ;

DURAN, M ;

BEEMER, FA ;

DEBREE, PK ;

WEITSBINNERTS, JJ ;

PENDERS, TJ ;

VANDERWOUDE, JK .

CLINICA CHIMICA ACTA, 1984, 141 (2-3) :227-234

[3]

CHABNER BA, 1985, CANCER PRINCIPLES PR, P287

[4]

CHABNER BA, 1982, PHARM PRINCIPLES CAN, P183

[5]

GIBALDI M, 1982, PHARMACOKINETICS

[6]

HEGGIE GD, 1987, CANCER RES, V47, P2203

[7] BIOCHEMICAL BASIS FOR FLUOROURACIL NEUROTOXICITY [J].

KOENIG, H ;

PATEL, A .

ARCHIVES OF NEUROLOGY, 1970, 23 (02) :155-&

[8]

KOENIG H, 1969, Transactions of the American Neurological Association, V94, P290

[9]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[10] ORGANIC BRAIN-SYNDROME SECONDARY TO 5-FLUOROURACIL TOXICITY [J].

LYNCH, HT ;

DROSZCZ, CP ;

ALBANO, WA ;

LYNCH, JF .

DISEASES OF THE COLON & RECTUM, 1981, 24 (02) :130-131

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