HB-FUKUOKA [BETA2(NA2)HIS-]TYR] - A NEW MUTATION AT THE 2,3-DIPHOSPHOGLYCERATE BINDING-SITE

被引：18

作者：

HARANO, T

HARANO, K

UEDA, S

IMAI, K

OHKUMA, A

KOYA, Y

TAKAHASHI, H

机构：

[1] OSAKA UNIV, SCH MED,DEPT PHYSICOCHEM PHYSIOL, OSAKA 530, JAPAN

[2] FUKUOKA SHI MED ASSOC, CLIN LAB, FUKUOKA 810, JAPAN

[3] TOSOH CO, DIV RES & DEV, TOKYO 107, JAPAN

来源：

HEMOGLOBIN | 1990年 / 14卷 / 02期

关键词：

D O I：

10.3109/03630269009046961

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two abnormal hemoglobins (Hbs) with a substituted amino acid residue at the 2nd position of the B chain, a part of the 2,3-diphosphoglycerate (2,3-DPG) binding site, have been reported: Hb Deer Lodge (His+Arg) (1) and Hb Okayama (His-Gln) (2). In 1985, we found a new abnormal Hb during assay of Hb A1c and Hb A1 by high performance liquid chromatography (HPLC) in a 38-year-old Japanese female patient suffering from diabetes mellitus. This abnormal Hb was designated Hb Fukuoka [B2(NA2)HisTyr] after the name of the city where the patient lived. Herein, we describe the structural analysis and functional properties of this Hb. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：199 / 205

页数：7

共 12 条

[1] X-RAY-DIFFRACTION STUDY OF BINDING OF 2,3-DIPHOSPHOGLYCERATE TO HUMAN DEOXYHEMOGLOBIN [J].