SIMULTANEOUS DETERMINATION OF NORMAL-HEXANE, 2-HEXANONE AND 2,5-HEXANEDIONE IN BIOLOGICAL TISSUES BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：14

作者：

WHITE, EL

BUS, JS

HECK, HDA

机构：

[1] Chemical Industry Institute of Toxicology, North Carolina, 27709, Post Office Box 12137, Research Triangle Park

来源：

BIOMEDICAL MASS SPECTROMETRY | 1979年 / 6卷 / 04期

关键词：

D O I：

10.1002/bms.1200060408

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A quantitative method is reported for the determination of n‐hexane, 2‐hexanone and 2,5‐hexanedione in biological tissues by stable isotope dilution using gas chromatography mass spectrometry. n‐[2H14]Hexane, 2‐[2H5]hexanone and 2,5‐[2H10]hexanedione are used as the isotopic diluents. After tissue homogenization and extraction of the three compounds in the presence of the deuterated internal standards, analysis is carried out in a single gas chromatographic injection by selected ion monitoring. Principal advantages of the technique are the ease of sample handling, rapidity of analysis and low limits of detection. The methodology is used to determine the organ distribution, pharmacokinetics and metabolism of n‐hexane to 2‐hexanone and 2,5‐hexanedione in rats following inhalation exposure. Copyright © 1979 Heyden & Son Ltd

引用

页码：169 / 172

页数：4

共 9 条

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[9]

WHITE E, UNPUBLISHED

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