PEPTIDE-SYNTHESIS UNDER HIGH-PRESSURE

被引：5

作者：

GANTE, J ^{[1
]}

KALTHOF, U ^{[1
]}

KLARNER, FG ^{[1
]}

WEBER, T ^{[1
]}

机构：

[1] RUHR UNIV BOCHUM,FAK CHEM,W-4630 BOCHUM 1,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 09期

关键词：

D O I：

10.1002/anie.199010251

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nonactivated amino acid alkyl esters (as ester components) and amino acid Na salts (as amine components) form dipeptides at room temperature under pressures of 7 and 11 kbar [Eq. (a)]. The advantages of this method include the use of inexpensive, readily accessible starting materials and the easy separation of byproducts (alcohols). (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

引用

收藏

页码：1025 / 1026

页数：2

相关论文

共 9 条

[1] COBALT(III)-MEDIATED PEPTIDE-SYNTHESIS .1. COBALT(III)-ACTIVATED AMINO-ACID METHYL-ESTERS AND THE SYNTHESIS OF DIPEPTIDES [J].

CLARK, CR ;

TASKER, RF ;

BUCKINGHAM, DA ;

KNIGHTON, DR ;

HARDING, DRK ;

HANCOCK, WS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (23) :7023-7025

[2]

DEIMER KH, 1974, METHOD ORGAN CHEM, V15, P405

[3] ENANTIOMER LABELING, A METHOD FOR THE QUANTITATIVE-ANALYSIS OF AMINO-ACIDS [J].

FRANK, H ;

NICHOLSON, GJ ;

BAYER, E .

JOURNAL OF CHROMATOGRAPHY, 1978, 167 (DEC) :187-196

[4] CHEMISTRY UNDER HIGH-PRESSURE - EFFECTS OF HIGH-PRESSURE ON REACTIONS IN ORGANIC-CHEMISTRY [J].

KLARNER, FG .

CHEMIE IN UNSERER ZEIT, 1989, 23 (02) :53-63

[5] COBALT(III)-MEDIATED PEPTIDE-SYNTHESIS .2. SYNTHESIS OF TETRAPEPTIDES AND [LEU5]ENKEPHALIN [J].

KNIGHTON, DR ;

HARDING, DRK ;

FRIAR, MJ ;

HANCOCK, WS ;

REYNOLDS, GD ;

CLARK, CR ;

TASKER, RF ;

BUCKINGHAM, DA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (23) :7025-7026

[6] ACTIVATION AND REACTION VOLUMES IN SOLUTION .2. [J].

VANELDIK, R ;

ASANO, T ;

LENOBLE, WJ .

CHEMICAL REVIEWS, 1989, 89 (03) :549-688

[7]

WENDLBERGER G, 1974, METHOD ORGAN CHEM, V15, P3

[8]

WIELAND T, 1964, LIEBIGS ANN CHEM, V680, P125

[9] PEPTIDE-SYNTHESIS UNDER HIGH-PRESSURE - COUPLING REACTIONS OF N-(BENZYLOXYCARBONYL)-AMINO ACID N-HYDROXYSUCCINIMIDE ESTERS WITH N-(CARBOXYMETHYL)AMINO ACID DIESTERS [J].

YAMADA, T ;

MANABE, Y ;

MIYAZAWA, T ;

KUWATA, S ;

SERA, A .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (22) :1500-1501