MEASURING ANXIETY IN NONHUMAN-PRIMATES - EFFECT OF LORAZEPAM ON MACAQUE SCRATCHING

被引：74

作者：

SCHINO, G

TROISI, A

PERRETTA, G

MONACO, V

机构：

[1] UNIV ROME LA SAPIENZA,DIPARTIMENTO GENET & BIOL MOLEC,I-00185 ROME,ITALY

[2] ENTE NAZL ENERGIA ATOM,CTR RIC ENERGIA CASACCIA,ANIM ESPERIMENTO LAB,ROME,ITALY

[3] UNIV ROME 2,CATTEDRA CLIN PSYCHIAT,ROME,ITALY

[4] CNR,IST MED SPERIMENTALE,ROME,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 04期

关键词：

ANXIETY; SCRATCHING; NONHUMAN PRIMATES; BENZODIAZEPINES; DISPLACEMENT ACTIVITIES; ANIMAL MODELS; ETHOPHARMACOLOGY;

D O I：

10.1016/0091-3057(91)90258-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Lorazepam (0.2 mg/kg IM) was given to group-living female macaques to assess the effect of anxiolytic treatment on scratching, a behavior pattern referred to as a displacement activity in the primate literature. Lorazepam selectively diminished scratching behavior. The drug effect was status-dependent: especially low-ranking animals showed a marked reduction in scratching. Lorazepam exerted a direct effect on scratching, that is the effect was not due to sedation or mediated by the influence of the drug on other behaviors. These results provide pharmacological validation to the ethological finding that scratching may be a manifestation of anxiety in monkeys. In addition, they suggest to use scratching as a behavioral measure in studies investigating nonhuman primate models of anxiety.

引用

页码：889 / 891

页数：3

共 14 条

[1] FUNCTIONAL-ASPECTS OF RECONCILIATION AMONG CAPTIVE LONG-TAILED MACAQUES (MACACA-FASCICULARIS) [J].