INCREASE OF INTESTINAL INTRAEPITHELIAL LYMPHOCYTES EXPRESSING CD8 ANTIGEN FOLLOWING CHALLENGE INFECTION WITH EIMERIA ACERVULINA

被引：59

作者：

LILLEHOJ, HS ^{[1
]}

BACON, LD ^{[1
]}

机构：

[1] USDA,REG POULTRY RES LAB,E LANSING,MI 48823

来源：

AVIAN DISEASES | 1991年 / 35卷 / 02期

关键词：

D O I：

10.2307/1591179

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Eimerian infection-induced changes in the intestinal intraepithelial lymphocyte (IEL) subpopulations expressing CD8 antigen (cytotoxic/suppressor T cells) or antigen-specific T cell receptor (TCR) heterodimer alpha-beta (TCR2) or gamma-delta (TCR1) were investigated in F2 crosses of 151(5) B-congenic chickens differing for the major histocompatiblity complex (MHC). Duodenum TCR2+ IEL were increased in B2B2 and B5B5 chickens 7 days following secondary infection. Two-color immunofluorescence revealed that the majority of CD8+ cells in the duodenum intraepithelium of immune chickens expressed TCR2. A significant increase in the duodenum TCR2+CD8+ and TCR1+CD8+ IEL occurred in B2B2 chickens, which developed significantly less oocyst production than the B5B5 chickens following challenge infection. The results suggest that a significant increase in the duodenum CD8+ IEL may reflect an enhanced acquired immunity of B2B2 chickens.

引用

页码：294 / 301

页数：8

共 33 条

[1] STRUCTURE, FUNCTION, AND SEROLOGY OF THE T-CELL ANTIGEN RECEPTOR COMPLEX [J].