ACTIVIN-A INCREASES INTRACELLULAR FREE CALCIUM CONCENTRATIONS IN RAT PANCREATIC-ISLETS

被引：29

作者：

SHIBATA, H

YASUDA, H

SEKINE, N

MINE, T

TOTSUKA, Y

KOJIMA, I

机构：

[1] GUNMA UNIV,INST ENDOCRINOL,MAEBASHI,GUNMA 371,JAPAN

[2] UNIV TOKYO,SCH MED,DEPT INTERNAL MED 4,TOKYO 113,JAPAN

[3] KANTOH TEISIN HOSP,DIV ENDOCRINOL & METAB,KANTOH TEISIN,JAPAN

来源：

FEBS LETTERS | 1993年 / 329卷 / 1-2期

关键词：

ACTIVIN-A; CALCIUM; ISLET; INSULIN SECRETION; CALCIUM INFLUX; CALCIUM CHANNEL;

D O I：

10.1016/0014-5793(93)80220-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activin A stimulated insulin secretion in rat pancreatic islets, an effect that was attenuated by reduction of extracellular Ca2+ and abolished by either nitrendipine or verapamil. Activin A increased intracellular the free Ca2+ concentration, [Ca2+]i in fura-2-loaded islets. Activin A-mediated elevation of [Ca2+]i was abolished by the reduction of extracellular Ca2+ or the addition of nifedipine. In addition, activin A did not increase [Ca2+]i in the presence of diazoxide, an opener of ATP-sensitive K+ channels. These results suggest that activin A increases insulin secretion by stimulating Ca2+ entry.

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页码：194 / 198

页数：5

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