A theoretical calculation is presented which extends Wright''s island model of drift and migration to differential migration between the 2 sexes. In this circumstance, local demes no longer have Hardy-Weinberg frequencies. There may be local heterozygote excess or deficiency depending on whether migration occurs before or after mating. The magnitude of the local departure from Hardy-Weinberg is directly proportional to the difference between the migration parameters of the 2 sexes. Studies where genetic markers are used for infering population structure are discussed. An example from a study of Marmot colonies is cited.